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recombinant mouse sclerostin sost  (R&D Systems)


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    R&D Systems recombinant mouse sclerostin sost
    Recombinant Mouse Sclerostin Sost, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 29 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/recombinant mouse sclerostin sost/product/R&D Systems
    Average 94 stars, based on 29 article reviews
    recombinant mouse sclerostin sost - by Bioz Stars, 2026-03
    94/100 stars

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    Reduced osteoblast and osteoclast activity in 20-week-old male db/db diabetic mice. H&E (A) and TRAP (B) staining show reduced activity of both osteoblasts and osteoclasts in db/db mice (n = 5 per group). (C) Serum analysis shows lower osteocalcin, TRACP 5b, and CTX-1 levels, and higher <t>sclerostin</t> levels in db/db mice (n = 4-5 per group). Data are presented as mean ± SD, analyzed by unpaired Student’s t-test. *p < 0.05, **p < 0.01.
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    Reduced osteoblast and osteoclast activity in 20-week-old male db/db diabetic mice. H&E (A) and TRAP (B) staining show reduced activity of both osteoblasts and osteoclasts in db/db mice (n = 5 per group). (C) Serum analysis shows lower osteocalcin, TRACP 5b, and CTX-1 levels, and higher <t>sclerostin</t> levels in db/db mice (n = 4-5 per group). Data are presented as mean ± SD, analyzed by unpaired Student’s t-test. *p < 0.05, **p < 0.01.
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    Reduced osteoblast and osteoclast activity in 20-week-old male db/db diabetic mice. H&E (A) and TRAP (B) staining show reduced activity of both osteoblasts and osteoclasts in db/db mice (n = 5 per group). (C) Serum analysis shows lower osteocalcin, TRACP 5b, and CTX-1 levels, and higher <t>sclerostin</t> levels in db/db mice (n = 4-5 per group). Data are presented as mean ± SD, analyzed by unpaired Student’s t-test. *p < 0.05, **p < 0.01.
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    Image Search Results


    Reduced osteoblast and osteoclast activity in 20-week-old male db/db diabetic mice. H&E (A) and TRAP (B) staining show reduced activity of both osteoblasts and osteoclasts in db/db mice (n = 5 per group). (C) Serum analysis shows lower osteocalcin, TRACP 5b, and CTX-1 levels, and higher sclerostin levels in db/db mice (n = 4-5 per group). Data are presented as mean ± SD, analyzed by unpaired Student’s t-test. *p < 0.05, **p < 0.01.

    Journal: Frontiers in Cell and Developmental Biology

    Article Title: Localized sclerostin accumulation in osteocyte lacunar-canalicular system is associated with cortical bone microstructural alterations and bone fragility in db/db male mice

    doi: 10.3389/fcell.2025.1562764

    Figure Lengend Snippet: Reduced osteoblast and osteoclast activity in 20-week-old male db/db diabetic mice. H&E (A) and TRAP (B) staining show reduced activity of both osteoblasts and osteoclasts in db/db mice (n = 5 per group). (C) Serum analysis shows lower osteocalcin, TRACP 5b, and CTX-1 levels, and higher sclerostin levels in db/db mice (n = 4-5 per group). Data are presented as mean ± SD, analyzed by unpaired Student’s t-test. *p < 0.05, **p < 0.01.

    Article Snippet: For recombinant sclerostin (SCL) treatment, IDG-SW3 cells were treated with 100 ng/mL recombinant mouse sclerostin (HY- P70717 , MCE, China) for 48 h following 28 days of osteogenic induction.

    Techniques: Activity Assay, Staining

    Localized sclerostin accumulation and increased expression of PLR-related proteins in 20-week-old male db/db diabetic mice cortical bone. Immunohistochemical staining shows increased expression of CTSK (A) , MMP-13 (B) , and sclerostin (C) within the osteocyte LCS of db/db mice compared to WT mice. Linear regression analysis (D) reveals a significant positive correlation between sclerostin expression and CTSK and MMP-13 using combined data from both groups. Data are presented as mean ± SD. Statistical analysis was performed using an unpaired Student’s t-test for (A–C) (n = 5 mice per group) and Pearson correlation for (D) . *p < 0.05, **p < 0.01, ***p < 0.001.

    Journal: Frontiers in Cell and Developmental Biology

    Article Title: Localized sclerostin accumulation in osteocyte lacunar-canalicular system is associated with cortical bone microstructural alterations and bone fragility in db/db male mice

    doi: 10.3389/fcell.2025.1562764

    Figure Lengend Snippet: Localized sclerostin accumulation and increased expression of PLR-related proteins in 20-week-old male db/db diabetic mice cortical bone. Immunohistochemical staining shows increased expression of CTSK (A) , MMP-13 (B) , and sclerostin (C) within the osteocyte LCS of db/db mice compared to WT mice. Linear regression analysis (D) reveals a significant positive correlation between sclerostin expression and CTSK and MMP-13 using combined data from both groups. Data are presented as mean ± SD. Statistical analysis was performed using an unpaired Student’s t-test for (A–C) (n = 5 mice per group) and Pearson correlation for (D) . *p < 0.05, **p < 0.01, ***p < 0.001.

    Article Snippet: For recombinant sclerostin (SCL) treatment, IDG-SW3 cells were treated with 100 ng/mL recombinant mouse sclerostin (HY- P70717 , MCE, China) for 48 h following 28 days of osteogenic induction.

    Techniques: Expressing, Immunohistochemical staining, Staining

    Effects of high glucose and recombinant Sclerostin (SCL) on osteocyte remodeling markers in IDG-SW3 cells. (A) Representative images showing osteocytic differentiation over 28 days, including DMP1-GFP fluorescence, ALP staining, and ARS staining. (B) Time-course expression of late osteocytic markers (FGF23, MEPE, Pdpn, Phex, and Sost) over 28 days, presented as relative fold induction. (C) Elevated mRNA expression of Sost, Ctsk, Mmp-13, and Atp6v0d2 in IDG-SW3 cells treated with 20 mM glucose compared to control cells. (D) Upregulation of Ctsk and Mmp-13 mRNA levels in IDG-SW3 cells treated with recombinant SCL compared to vehicle control. Data represent mean ± SD from three independent experiments (n = 3). Statistical significance is indicated (*p < 0.05, **p < 0.01, ****p < 0.0001).

    Journal: Frontiers in Cell and Developmental Biology

    Article Title: Localized sclerostin accumulation in osteocyte lacunar-canalicular system is associated with cortical bone microstructural alterations and bone fragility in db/db male mice

    doi: 10.3389/fcell.2025.1562764

    Figure Lengend Snippet: Effects of high glucose and recombinant Sclerostin (SCL) on osteocyte remodeling markers in IDG-SW3 cells. (A) Representative images showing osteocytic differentiation over 28 days, including DMP1-GFP fluorescence, ALP staining, and ARS staining. (B) Time-course expression of late osteocytic markers (FGF23, MEPE, Pdpn, Phex, and Sost) over 28 days, presented as relative fold induction. (C) Elevated mRNA expression of Sost, Ctsk, Mmp-13, and Atp6v0d2 in IDG-SW3 cells treated with 20 mM glucose compared to control cells. (D) Upregulation of Ctsk and Mmp-13 mRNA levels in IDG-SW3 cells treated with recombinant SCL compared to vehicle control. Data represent mean ± SD from three independent experiments (n = 3). Statistical significance is indicated (*p < 0.05, **p < 0.01, ****p < 0.0001).

    Article Snippet: For recombinant sclerostin (SCL) treatment, IDG-SW3 cells were treated with 100 ng/mL recombinant mouse sclerostin (HY- P70717 , MCE, China) for 48 h following 28 days of osteogenic induction.

    Techniques: Recombinant, Fluorescence, Staining, Expressing, Control

    Reduced osteoblast and osteoclast activity in 20-week-old male db/db diabetic mice. H&E (A) and TRAP (B) staining show reduced activity of both osteoblasts and osteoclasts in db/db mice (n = 5 per group). (C) Serum analysis shows lower osteocalcin, TRACP 5b, and CTX-1 levels, and higher sclerostin levels in db/db mice (n = 4-5 per group). Data are presented as mean ± SD, analyzed by unpaired Student’s t-test. *p < 0.05, **p < 0.01.

    Journal: Frontiers in Cell and Developmental Biology

    Article Title: Localized sclerostin accumulation in osteocyte lacunar-canalicular system is associated with cortical bone microstructural alterations and bone fragility in db/db male mice

    doi: 10.3389/fcell.2025.1562764

    Figure Lengend Snippet: Reduced osteoblast and osteoclast activity in 20-week-old male db/db diabetic mice. H&E (A) and TRAP (B) staining show reduced activity of both osteoblasts and osteoclasts in db/db mice (n = 5 per group). (C) Serum analysis shows lower osteocalcin, TRACP 5b, and CTX-1 levels, and higher sclerostin levels in db/db mice (n = 4-5 per group). Data are presented as mean ± SD, analyzed by unpaired Student’s t-test. *p < 0.05, **p < 0.01.

    Article Snippet: For recombinant sclerostin (SCL) treatment, IDG-SW3 cells were treated with 100 ng/mL recombinant mouse sclerostin (HY- P70717 , MCE, China) for 48 h following 28 days of osteogenic induction.

    Techniques: Activity Assay, Staining

    Localized sclerostin accumulation and increased expression of PLR-related proteins in 20-week-old male db/db diabetic mice cortical bone. Immunohistochemical staining shows increased expression of CTSK (A) , MMP-13 (B) , and sclerostin (C) within the osteocyte LCS of db/db mice compared to WT mice. Linear regression analysis (D) reveals a significant positive correlation between sclerostin expression and CTSK and MMP-13 using combined data from both groups. Data are presented as mean ± SD. Statistical analysis was performed using an unpaired Student’s t-test for (A–C) (n = 5 mice per group) and Pearson correlation for (D) . *p < 0.05, **p < 0.01, ***p < 0.001.

    Journal: Frontiers in Cell and Developmental Biology

    Article Title: Localized sclerostin accumulation in osteocyte lacunar-canalicular system is associated with cortical bone microstructural alterations and bone fragility in db/db male mice

    doi: 10.3389/fcell.2025.1562764

    Figure Lengend Snippet: Localized sclerostin accumulation and increased expression of PLR-related proteins in 20-week-old male db/db diabetic mice cortical bone. Immunohistochemical staining shows increased expression of CTSK (A) , MMP-13 (B) , and sclerostin (C) within the osteocyte LCS of db/db mice compared to WT mice. Linear regression analysis (D) reveals a significant positive correlation between sclerostin expression and CTSK and MMP-13 using combined data from both groups. Data are presented as mean ± SD. Statistical analysis was performed using an unpaired Student’s t-test for (A–C) (n = 5 mice per group) and Pearson correlation for (D) . *p < 0.05, **p < 0.01, ***p < 0.001.

    Article Snippet: For recombinant sclerostin (SCL) treatment, IDG-SW3 cells were treated with 100 ng/mL recombinant mouse sclerostin (HY- P70717 , MCE, China) for 48 h following 28 days of osteogenic induction.

    Techniques: Expressing, Immunohistochemical staining, Staining

    Effects of high glucose and recombinant Sclerostin (SCL) on osteocyte remodeling markers in IDG-SW3 cells. (A) Representative images showing osteocytic differentiation over 28 days, including DMP1-GFP fluorescence, ALP staining, and ARS staining. (B) Time-course expression of late osteocytic markers (FGF23, MEPE, Pdpn, Phex, and Sost) over 28 days, presented as relative fold induction. (C) Elevated mRNA expression of Sost, Ctsk, Mmp-13, and Atp6v0d2 in IDG-SW3 cells treated with 20 mM glucose compared to control cells. (D) Upregulation of Ctsk and Mmp-13 mRNA levels in IDG-SW3 cells treated with recombinant SCL compared to vehicle control. Data represent mean ± SD from three independent experiments (n = 3). Statistical significance is indicated (*p < 0.05, **p < 0.01, ****p < 0.0001).

    Journal: Frontiers in Cell and Developmental Biology

    Article Title: Localized sclerostin accumulation in osteocyte lacunar-canalicular system is associated with cortical bone microstructural alterations and bone fragility in db/db male mice

    doi: 10.3389/fcell.2025.1562764

    Figure Lengend Snippet: Effects of high glucose and recombinant Sclerostin (SCL) on osteocyte remodeling markers in IDG-SW3 cells. (A) Representative images showing osteocytic differentiation over 28 days, including DMP1-GFP fluorescence, ALP staining, and ARS staining. (B) Time-course expression of late osteocytic markers (FGF23, MEPE, Pdpn, Phex, and Sost) over 28 days, presented as relative fold induction. (C) Elevated mRNA expression of Sost, Ctsk, Mmp-13, and Atp6v0d2 in IDG-SW3 cells treated with 20 mM glucose compared to control cells. (D) Upregulation of Ctsk and Mmp-13 mRNA levels in IDG-SW3 cells treated with recombinant SCL compared to vehicle control. Data represent mean ± SD from three independent experiments (n = 3). Statistical significance is indicated (*p < 0.05, **p < 0.01, ****p < 0.0001).

    Article Snippet: For recombinant sclerostin (SCL) treatment, IDG-SW3 cells were treated with 100 ng/mL recombinant mouse sclerostin (HY- P70717 , MCE, China) for 48 h following 28 days of osteogenic induction.

    Techniques: Recombinant, Fluorescence, Staining, Expressing, Control